ESO has recently released an Instrumentation Roadmap for the E-ELT that foresees a high-resolution spectrograph either as Instrument Nr.4 or Nr.5. The optimal balance of the major science drivers for such an instrument need still to be defined. The aim of the workshop is to (further) define the science cases and science requirements for E-ELT HIRES, by bringing together people interested in the matter. This should be a rather informal meeting of about 50 participants.