High-Energy astrophysics is a crucial element of modern astrophysics and is particularly well suited to study matter under extreme conditions, black holes and warm/hot baryons in the dark matter potential wells of the cosmic web. Currently several high-energy satellite missions are working successfully in orbit and ground-based Cherenkov telescopes are providing exciting new results. The next decade will see a series of international missions in the gamma and X-ray range, starting with the launch of the NASA GLAST mission. The Russian Spektr-Röntgen-Gamma mission will carry a suite of powerful new instruments to study in particular clusters of galaxies and Dark Energy. Simbol-X the first formation flying telescope will provide a sensitivity jump of several orders of magnitude in the hard X-ray range. Finally, XEUS, the X-ray evolving Universe Spectroscopy mission has been selected in the ESA Cosmic Vision programme as one of the candidates for large missions in the next decade. In this presentation I give a short overview of the scientific and technical highlights of these missions.